Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/EX-hAr7CoEs/130719085257.htm
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Friday, July 19, 2013
Nondrinkers may have higher mortality risk than light drinkers, but reasons for abstaining make a big difference
[unable to retrieve full-text content]As a class, people who don't drink at all have a higher mortality risk than light drinkers. But nondrinkers are a diverse bunch, and the reasons people have for abstaining affects their individual mortality risk, in some cases lowering it on par with the risk for light drinkers, according to a new study. Scientists calculated the mortality risk for each subgroup compared with the mortality risk for light drinkers, and they found that the risks varied markedly.
Mexico?s First Openly Gay Mayor Sung His Way To Victory, ?Not In Favor? Of Gay Marriage
?I?m not in favor of gay marriage, I don?t share that view, because we are still very small town ? in short, we?re not prepared, in my view,? the 47-year-old gay bar owner told the AP. ?Not yet, anyway, because we have strong roots in our religion, and in our customs.?
Medrano is the mayor of Fresnillo, part of the state of Zacatecas, where, he says, ?there are 258 villages full of tough country people, who don?t necessarily have much information on what?s happening elsewhere, and have even less of an automatic sympathy with their gay mayor.?
Fresnillo and the surrounding area have been plagued by gang violence as hacked up and decapitated bodies have turned up? in an ongoing drug turf war. So how, then, did an? openly gay mayor get elected?
Well, Medrano ran on a public safety reform platform, calling for cooperation with state and federal police as well as routine vetting of the notoriously unscrupulous local police force. Oh, and he?s also got the voice. Of. An. Angel.
In addition to owning a gay bar for the better part of two decades, Medrano is a singer and, according to the AP, ?singing is one of the areas where Mexico has readily accepted gays.?
?Given that I?m a singer, people know that aspect of me,? Medrano said. He also distanced himself from gay rights in his campaign and, as a Roman Catholic, does not want to go against the church. While some may call him an Uncle Tom, or an Uncle Arthur, for shying away from gay politics, Medrano is critical of closeted politicians and ?very proud? to be the first openly gay mayor in the country.
He?s also got the backing of one of Mexicao?s foemost gay rights advocacy groups, Letra ?S?, which sees Medrano?s victory as a sign of the times. ?This shows that our human rights system is providing some protection,? director Alejandro Brito said. ?Because, even though there is no public majority in favor of electing gay politicians, he (Medrano) knows that the legal framework will protect him.?
?It is now more risky for a political rival to be openly homophobic,? Brito added, ?than it is to be a homosexual candidate.?
Photos: Benjamin Medrano Quezada Facebook
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Thursday, July 18, 2013
Mayor Annise Parker wants to improve the lack of CPR training in low-income areas
khou.com
Posted on July 17, 2013 at 4:48 PM
Updated today at 5:44 PM
HOUSTON -- Shirley King has been the secretary at her Sunnyside church for more than 20 years. She's also a retired nurse, who's tried to teach some of her neighbors how to perform CPR.
"I think the big thing is just the fear factor,? King said. ?Not knowing what's going to happen, not knowing how to do it and what's going to happen to you. A lot of people are afraid."
A team of experts from Rice University has seen those same tendencies in low-income minority areas all throughout Houston. Most of those areas have higher numbers of heart attacks and fewer people either willing or able to administer CPR.
Their findings were just reported in the American Journal of Preventive Medicine.
They convinced Houston?s mayor and other city leaders that it?s time to try something new.
?We have to be healthier,? said Houston Mayor Annise Parker. "Each of us has the abilities in our own hands to save lives."
The city wants to save lives by partnering with churches to teach bystander CPR which is a hands-only approach, unlike the old technique that required mouth-to-mouth contact.
"We have to get people who are willing to get down on their knees, put their hands on a chest and conduct CPR,? said Dr. David Perrse with the Houston Public Health Authority.
Recently a member of King?s church collapsed from a heart attack during service.
"So I did CPR along with others who would help until the paramedics got there,? King said.
She believes her church is ready to lend a hand. "If the city is willing, we would be more than willing to step out and help," King said.
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Emma Roberts arrested for domestic dispute
Celebs 
12 hours ago
A reported domestic incident on July 7 got out of control and ended up with "American Horror Story" actress Emma Roberts being arrested in Montreal, then later released, according to multiple reports.
The Hollywood Reporter said that a Montreal police spokesperson told them on Tuesday that local officers were called to a hotel "concerning a conflict" between a man and a woman at 2 a.m. The woman was arrested, but as the spokesperson added, "No charges were pressed on her."
Without those charges, no name was officially disclosed, said THR; E! Online connected Roberts -- whose aunt is Julia Roberts and father is actor Eric Roberts -- with the arrest, however.
Roberts, 22, has been dating Evan Peters, 26, who was also reportedly in the hotel room and on the other side of the dispute. He was not taken into custody.
The couple released a joint statement later, noting, "It was an unfortunate incident and misunderstanding. Ms. Roberts was released after questioning and the couple are working together to move past it."
Source: http://www.today.com/entertainment/emma-roberts-released-after-domestic-dispute-arrest-6C10661026
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Slippery Nate: Adelle Waldman Talks About 'The Love Affairs of ...
What do men want? Adelle Waldman addresses this question in her first novel, ?The Love Affairs of Nathaniel P.? Nate is an aspiring writer in Brooklyn, and Ms. Waldman writes from his perspective, closely exploring his conscious and unconscious habits in relating to women. In The New York Times Book Review, Jess Walter called the novel ?a smart, engaging 21st-century comedy of manners.? In a recent e-mail interview, Ms. Waldman discussed how she got inside Nate?s head, whether readers should dislike him, her literary influences and more. Below are edited excerpts from the conversation:
Q.
What appealed to you about writing from so firmly inside a man?s head? Was it just another character you wanted to get to the bottom of, or was there a conscious feeling that this would be provocative in a useful way?
A.
I had a years-old desire to write about certain experiences that I had had in romantic relationships, which over time I realized were similar to the experiences of other women. Many women I knew struggled to make sense of men we were involved with who were by no means wholly bad people ? and who were often very talented and charming in other respects ? but whose behavior in a romantic context seemed both unpredictable and hurtful. As widespread as this experience seemed to be among women, I didn?t really see it well represented in contemporary literature, though a version of it is certainly represented in 18th- and 19th-century fiction.
Q.
Some readers react in a strongly negative way to Nate. Was it your intention to elicit such reactions?
A.
I didn?t think of it in those terms. I consciously tried not to. Although I wanted to scrutinize his thinking and his behavior, I also wanted to be fair in my depiction. I wanted Nate to be as layered and as slippery as any actual living male and to be true enough that readers would recognize parts of themselves in him. I didn?t want to be tempted to bend the material to make him conform to an idea; that seemed like a recipe for reducing complexity. I thought if I made him feel real, readers could judge for themselves.
Q.
Nate sometimes ?wondered whether he was a bit misogynistic.? Do you think he is? A bit, or more?
A.
I think the word ?misogynistic? isn?t quite right for what Nate is. I think he is an earnestly liberal, politically correct guy who genuinely believes in the stated aims of feminism, at least as far as equality goes, but I think he also harbors a good deal of reflexive sexism, some of which he is unaware of and some of which he acknowledges to himself but instinctively refrains from revealing to others. This affects his choice of romantic partner: intellectual or even moral equality is not a prerequisite for him. I also think he has a relationship to women?s appearances that I find troubling but not necessarily atypical.
Q.
Did you talk to male friends to help put Nate together, or was it more instinctual based on your experience in friendships and relationships? I?m thinking of lines like: ?Although it wasn?t something he?d admit aloud, [Nate] often thought women were either deep or reasonable, but rarely both.?
A.
It was more instinctual, although I have to acknowledge, with gratitude, the many little nuggets of insight I got from male friends over the years. But the main part of Nate?s emotional and intellectual life, that I have to take responsibility for ? if it doesn?t ring true, I can?t put the blame on any of my male friends.
In terms of the passage you quoted, that came out of my experience. I felt that as a woman I?ve encountered, in subtle ways, assumptions or prejudices about, say, the nature of women?s intelligence or our capacity for disinterested judgment. What I tried to do, in the novel, was to come up with a plausible account of the type of private thinking likely to underlie what I had experienced. Not that I think all men have the kind of thoughts I attribute to Nate. I do, however, suspect that many men tend to unconsciously consider their intellectual peers ? and competitors ? to be other men.
Q.
Who are some of your literary influences?
A.
I have to start with George Eliot. I spent my twenties reading mostly 19th-century novels, with a bit of 18th century mixed in. Besides Eliot, Samuel Richardson, Jane Austen, Stendhal, Flaubert and Tolstoy were among the writers I turned to most. One thing these authors have in common is that they pay close attention to moral life, that is, to how characters justify their behavior to themselves?their capacity or incapacity for honest self-criticism, for impartiality generally.
That said, when, in my 30s, I sat down to write this novel, I looked at the work of more contemporary writers. I didn?t want to write a 19th-century novel with an omniscient narrator and a lot of explicit moralizing. I turned to Jonathan Franzen and Richard Yates, as well as Philip Roth?s ?Goodbye, Columbus.? But ?The Corrections? and ?Revolutionary Road? were really my go-to books, the ones I reread most frequently.
Q.
How important a role does Brooklyn play as the novel?s locale? Could the story have been placed anywhere else?
A.
I once would have said that it wasn?t particularly important. It was just what I knew, so it is what I drew from, but what I primarily wanted to write about were relationship dynamics that are fairly universal. But one thing I learned while writing the book is just how much needs to go into a novel, into its every page, for the thing to feel at all vibrant or alive. Aside from the Brooklyn backdrop, I also found myself very interested in fleshing out the supporting characters, in Nate?s early years and in his status anxieties ? in many things other than his relationships with women.
Q.
Are there male writers who you think write particularly well from the female perspective?
A.
Tolstoy and Flaubert immediately come to mind. Of more contemporary writers, Norman Rush, in ?Mating.? Franzen is also terrific at writing from the female perspective. But it?s probably worth noting that all these authors are excellent at writing from the perspective of male characters too. I think what they possess is less a special gift for writing women than a terrific insight into people generally.
Q.
How have your male friends reacted to the book? Do they think you ?got them??
A.
By ?got them,? do you mean in a ?gotcha? sense of nailing them personally? To that I?d say no, I certainly hope not. But many of my male friends have told me that Nate rings true as a guy. Of course, they are my friends, so they?d probably be wary of telling me that they thought the character fell flat.
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Sony full frame NEX mirrorless camera rumors intensify
Sonyalpharumors has published several very interesting rumors, that if turn out to be true, will be a major step forward for the mirrorless market. For years many readers have been asking for a compact mirrorless full frame camera and it seems that finally Sony is getting ready to release one. This is not a big surprise after what the company was able to do with the RX1 in terms of camera size and image quality. Here is the recap of the rumored Sony full frame NEX mirrorless camera specifications:
- The price of the camera body will be under $3000
- The full frame NEX camera will be the first E-mount model with an on sensor 5 axis image stabilization
We already know that the Sony?E-mount can support a full frame sensor.
In the past Sony has filed several patents for full frame mirrorless lenses (at least one of them was designed for a curved sensor).
This entry was posted in Sony and tagged Sony full frame E-mount interchangeable lens camera. Bookmark the permalink. Trackbacks are closed, but you can .Source: http://feedproxy.google.com/~r/PhotoRumors/~3/9jmbAuS_TKY/
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Wednesday, July 17, 2013
Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vc09XLQcLY5NZzLUufRTlTvid7zjKoTFZNrDiwojIqBHN5tL3828X1CBuatRMD-nxDGm11cmEwTRo4RnhZCMoiMIuO8evu8xQ3ufEFHT8=s0-d){kind=small}
Public release date: 17-Jul-2013[ | E-mail |
Share ] Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
- The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors; innovative new treatments are needed.
- This laboratory study shows that a nanotechnology drug called SapC-DOPS crosses that barrier and targets brain-tumor cells and retards growth of tumor blood vessels.
- The findings also show how the agent targets tumor cells and recommend its further development as a novel treatment for glioblastoma.
COLUMBUS, Ohio An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier and kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).
The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels. The findings support further development of the drug as a novel treatment for brain tumors.
Glioblastoma multiforme is the most common and aggressive form of brain cancer, with a median survival of about 15 months. A major obstacle to improving treatment for the 3,470 cases of the disease expected in the United States this year is the blood-brain barrier, the name given to the tight fit of cells that make up the blood vessels in the brain. That barrier protects the brain from toxins in the blood but also keeps drugs in the bloodstream from reaching brain tumors.
"Few drugs have the capacity to cross the tumor blood-brain barrier and specifically target tumor cells," says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC James. "Our preclinical study indicates that SapC-DOPS does both and inhibits the growth of new tumor blood vessels, suggesting that this agent could one day be an important treatment for glioblastoma and other solid tumors."
The findings were published in a recent issue of the journal Molecular Therapy.
SapC-DOPS (saposin-C dioleoylphosphatidylserine), is a nanovesicle drug that has shown activity in glioblastoma, pancreatic cancer and other solid tumors in preclinical studies. The nanovesicles fuse with tumor cells, causing them to self-destruct by apoptosis.
Key findings of the study, which used two brain-tumor models, include:
- SapC-DOPS binds with exposed patches of the phospholipid phosphatidylserine (PtdSer) on the surface of tumor cells;
- Blocking PtdSer on cells inhibited tumor targeting;
- SapC-DOPS strongly inhibited brain-tumor blood-vessel growth in cell and animal models, probably because these cells also have high levels of exposed PtdSer.
- Hypoxic cells were sensitized to killing by SapC-DOPS.
"Based on our findings, we speculate that SapC-DOPS could have a synergistic effect when combined with chemotherapy or radiation therapy, both of which are known to increase the levels of exposed PtdSer on cancer cells," Kaur says.
###
Funding from the NIH/National Cancer Institute (grants CA158372, CA136017, CA136017, F31CA171733) and a New Drug State Key Project grant (009ZX09102-205) helped support this research.
Other researchers involved in this study were Jeffrey Wojton, Haritha Mathsyaraja, Walter H. Meisen, Nicholas Denton, Chang-Hyuk Kwon and Michael C. Ostrowski of The Ohio State University; and Zhengtao Chu, Lionel M.L. Chow, Mary Palascak, Robert Franco, Tristan Bourdeau, Sherry Thornton and Xiaoyang Qi of the University of Cincinnati.
The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only four centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 228-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top cancer hospitals in the nation as ranked by U.S.News & World Report.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 17-Jul-2013[ | E-mail |
Share ] Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
- The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors; innovative new treatments are needed.
- This laboratory study shows that a nanotechnology drug called SapC-DOPS crosses that barrier and targets brain-tumor cells and retards growth of tumor blood vessels.
- The findings also show how the agent targets tumor cells and recommend its further development as a novel treatment for glioblastoma.
COLUMBUS, Ohio An experimental drug in early development for aggressive brain tumors can cross the blood-brain tumor barrier and kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).
The laboratory and animal study also shows how the agent, called SapC-DOPS, targets tumor cells and blood vessels. The findings support further development of the drug as a novel treatment for brain tumors.
Glioblastoma multiforme is the most common and aggressive form of brain cancer, with a median survival of about 15 months. A major obstacle to improving treatment for the 3,470 cases of the disease expected in the United States this year is the blood-brain barrier, the name given to the tight fit of cells that make up the blood vessels in the brain. That barrier protects the brain from toxins in the blood but also keeps drugs in the bloodstream from reaching brain tumors.
"Few drugs have the capacity to cross the tumor blood-brain barrier and specifically target tumor cells," says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC James. "Our preclinical study indicates that SapC-DOPS does both and inhibits the growth of new tumor blood vessels, suggesting that this agent could one day be an important treatment for glioblastoma and other solid tumors."
The findings were published in a recent issue of the journal Molecular Therapy.
SapC-DOPS (saposin-C dioleoylphosphatidylserine), is a nanovesicle drug that has shown activity in glioblastoma, pancreatic cancer and other solid tumors in preclinical studies. The nanovesicles fuse with tumor cells, causing them to self-destruct by apoptosis.
Key findings of the study, which used two brain-tumor models, include:
- SapC-DOPS binds with exposed patches of the phospholipid phosphatidylserine (PtdSer) on the surface of tumor cells;
- Blocking PtdSer on cells inhibited tumor targeting;
- SapC-DOPS strongly inhibited brain-tumor blood-vessel growth in cell and animal models, probably because these cells also have high levels of exposed PtdSer.
- Hypoxic cells were sensitized to killing by SapC-DOPS.
"Based on our findings, we speculate that SapC-DOPS could have a synergistic effect when combined with chemotherapy or radiation therapy, both of which are known to increase the levels of exposed PtdSer on cancer cells," Kaur says.
###
Funding from the NIH/National Cancer Institute (grants CA158372, CA136017, CA136017, F31CA171733) and a New Drug State Key Project grant (009ZX09102-205) helped support this research.
Other researchers involved in this study were Jeffrey Wojton, Haritha Mathsyaraja, Walter H. Meisen, Nicholas Denton, Chang-Hyuk Kwon and Michael C. Ostrowski of The Ohio State University; and Zhengtao Chu, Lionel M.L. Chow, Mary Palascak, Robert Franco, Tristan Bourdeau, Sherry Thornton and Xiaoyang Qi of the University of Cincinnati.
The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only four centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 228-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top cancer hospitals in the nation as ranked by U.S.News & World Report.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-07/osum-ndc071713.php
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